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Your doctor may have spoken to you about whether Veoza is right for you, or you may have read about it in the media. Here’s some information about Veoza – what it helps with, how it works, who it is suited – and not suited – for and the benefits, risks and side effects.
Hot flushes and night sweats are the most common symptoms of the menopause experienced by around 80% of women at some stage of the menopause transition. Hormone replacement therapy (HRT) is the most effective way of managing these for most – but what about if you have been advised not to take HRT or you don’t want to?
This is where Veoza comes in. It is a new, non-hormonal medication that is designed to help manage moderate to severe vasomotor symptoms (hot flushes and night sweats) that occur as a result of the menopause.
The active ingredient in Veoza is called fezolinetant. This is a neurokinin 3 antagonist that works by blocking the neurokinin 3 receptors in the brain that play an important role in the regulation of body temperature – so it works to block the source of the hot flush. This means that it may be suitable to use in some conditions where you have been advised not to take HRT. It is important to note that it has not been studied in women who have been diagnosed with breast or other cancers. A discussion with a menopause specialist or oncologist is important when deciding whether Veoza is suitable for you to take.
Veoza comes in a tablet form containing 45mg of fezolinetant that will be swallowed every day. One box contains 28 tablets.
Hormone replacement therapy (HRT) is the most effective way of managing hot flushes and night sweats for most women, reducing symptoms frequency and intensity by up to 90%. A large clinical trial of fezolinetant published in March 2023 showed that after 12 weeks of use it reduced the frequency of hot flushes by about 60% in women with moderate or severe symptoms, compared with a 45% reduction in those who received a placebo .
Studies have shown that liver function blood tests can become abnormal in women taking Veoza. The liver function returned to normal when the Veoza was stopped. There are no current recommendations in the UK to monitor liver function but, at My Menopause Centre we recommend checking the liver function before you start taking Veoza and then 3 months after it is started. It will be discussed whether further liver function testing is required after this time on an individual basis.
That is why you will need a follow up appointment up to 3 months after the initial prescription, including monitoring of liver function blood tests, and ongoing follow up during treatment as advised by your doctor.
When Veoza was studied, the most common side effects included difficulty sleeping, diarrhoea, headache and abdominal pain, and some experienced abnormal liver function blood tests also. You should contact your prescribing doctor if you experience nausea, vomiting, yellowing of the eyes or skin (jaundice), pain in the right upper abdomen which may be signs of liver disease.
Veoza is now available privately in the UK. Unfortunately, Veoza is not yet available on the NHS. To be available on the NHS, a further appraisal of the clinical and cost-effectiveness by the National Institute of Clinical and Healthcare Agency (NICE) is required. The publication date of this is yet to be confirmed.
If you would like to discuss whether Veoza might be right for you, please book an appointment with one of the doctors in our clinic.
Dr Clare Spencer
Registered menopause specialist, GP and co-founder
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